Our main research focus is the understanding of multiple sclerosis (MS) physiopathology, the identification of biomarkers of MS progression and therapy response, the development of new computational models of MS disease impact and evolution as well as the investigation of mechanisms of structural remodeling/regeneration within the central nervous system of MS patients. Further, we investigate the physiopathology and brain plasticity of stroke, headache/ migraine and neuro-HIV. As well, we study quantitative spinal cord imaging biomarkers for motor neuron diseases, spinal muscular atrophy and post-polio syndrome. In addition, we develop and optimize digital health solutions and reliable, automatic tools for image processing.