In pursuit of digitalizing mammalian organisms for biomedical research, Dr. Jiqing Wu develops novel GenAI approaches that enable the simulation of virtual biological systems, disease states and organisms. This includes novel approaches to simulate the effects of treatment interventions and the simulation of complex functional networks in cell culture, animal models and human tissues.

IST-editing: Infinite spatial transcriptomic editing in a generated gigapixel mouse pup.
Jiqing Wu, Ingrid Berg, Viktor Koelzer.
Proceedings of The 7nd International Conference on Medical Imaging with Deep Learning, PMLR 250:1707-1724.

SST-editing: in silico spatial transcriptomic editing at single-cell resolution.
Jiqing Wu, Viktor H Koelzer.
Bioinformatics, Volume 40, Issue 3, March 2024, btae077.

Prognostic impact and causality of age on oncological outcomes in women with endometrial cancer: a multimethod analysis of the randomised PORTEC-1, PORTEC-2, and PORTEC-3 trials.
Wakkerman FC, Wu J, Putter H, Jürgenliemk-Schulz IM, Jobsen JJ, Lutgens LCHW, Haverkort MAD, de Jong MA, Mens JWM, Wortman BG, Nout RA, Léon-Castillo A, Powell ME, Mileshkin LR, Katsaros D, Alfieri J, Leary A, Singh N, de Boer SM, Nijman HW, Smit VTHBM, Bosse T, Koelzer VH, Creutzberg CL, Horeweg N.
Lancet Oncol. 2024 Jun;25(6):779-789. doi: 10.1016/S1470-2045(24)00142-6. Epub 2024 Apr 30. PMID: 38701815.

Automated causal inference in application to randomized controlled clinical trials.
Ji Q. Wu, Nanda Horeweg, Marco de Bruyn, Remi A. Nout, Ina M. Jürgenliemk-Schulz, Ludy C. H. W. Lutgens, Jan J. Jobsen, Elzbieta M. van der Steen-Banasik, Hans W. Nijman, Vincent T. H. B. M. Smit, Tjalling Bosse, Carien L. Creutzberg & Viktor H. Koelzer.
Nature Machine Intelligence, 4(5), 436-444. (2022).