Dr. Maxime Lafarge leads the applied computer vision research branch of the group with a focus on morpho-molecular classification problems. His research aims to discover unknown links between diseased tissue morphology captured in histopathology images and molecular data: the goal is to develop new diagnostic tools based on automated histopathology image analysis to improve patient stratification and further support treatment decisions.

Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy.
Lafarge MW, Domingo E, Sirinukunwattana K, Wood R, Samuel L, Murray G, Richman SD, Blake A, Sebag-Montefiore D, Gollins S, Klieser E, Neureiter D, Huemer F, Greil R, Dunne P, Quirke P, Weiss L, Rittscher J, Maughan T, Koelzer VH.
NPJ Precis Oncol. 2024 Apr 9;8(1):89. doi: 10.1038/s41698-024-00580-3.

Pathway level subtyping identifies a slow-cycling biological phenotype associated with poor clinical outcomes in colorectal cancer.
Malla SB, Byrne RM, Lafarge MW, Corry SM, Fisher NC, Tsantoulis PK, Mills ML, Ridgway RA, Lannagan TRM, Najumudeen AK, Gilroy KL, Amirkhah R, Maguire SL, Mulholland EJ, Belnoue-Davis HL, Grassi E, Viviani M, Rogan E, Redmond KL, Sakhnevych S, McCooey AJ, Bull C, Hoey E, Sinevici N, Hall H, Ahmaderaghi B, Domingo E, Blake A, Richman SD, Isella C, Miller C, Bertotti A, Trusolino L, Loughrey MB, Kerr EM, Tejpar S; S:CORT consortium; Maughan TS, Lawler M, Campbell AD, Leedham SJ, Koelzer VH, Sansom OJ, Dunne PD.
Nat Genet. 2024 Mar;56(3):458-472. doi: 10.1038/s41588-024-01654-5. Epub 2024 Feb 13.

Transcriptomics and proteomics reveal distinct biology for lymph node metastases and tumour deposits in colorectal cancer.
Brouwer NP, Webbink L, Haddad TS, Rutgers N, van Vliet S, Wood CS, Jansen PW, Lafarge MW; imCMS Consortium; de Wilt JH, Hugen N, Simmer F, Jamieson NB, Tauriello DV, Kölzer VH, Vermeulen M, Nagtegaal ID.
J Pathol. 2023 Dec;261(4):401-412. doi: 10.1002/path.6196. Epub 2023 Oct 4.

Towards computationally efficient prediction of molecular signatures from routine histology images.
Lafarge MW, Koelzer VH.
Lancet Digit Health. 2021 Dec;3(12):e752-e753. doi: 10.1016/S2589-7500(21)00232-6. Epub 2021 Oct 19.