The Core Facility Microcalorimetry uses a range of advanced thermal analysis technologies to study how materials and biological systems behave. Each method measures heat in a different way, allowing us to observe processes such as molecular interactions, material transitions, chemical reactions, and temperature patterns. Because heat is involved in nearly every physical, chemical, and biological change, these techniques provide powerful, non-invasive tools to better understand stability, performance, and behavior under real-world conditions.
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S. Freund, DBE
Isothermal microcalorimetry measures extremely small heat changes from a sample kept at a constant temperature. Because almost all physical, chemical, and biological processes involve some heat change, tracking this heat allows you to “watch” those processes in real time without needing to disturb the sample. It’s often used to study things like chemical reactions, how materials degrade over time, or how living cells grow, providing a sensitive, non-invasive window into what’s happening inside a system.
Isothermal titrationcalorimetry focuses specifically on the heat released or absorbed when two molecules interact, such as a drug binding to a protein. This allows to measure how strongly they bind and how much energy is involved without needing to modify or alter the molecules.

S. Freund, DBE
TAMIII and TAMIV - Isothermal microcalorimeters (brochure)
| specifications | Nanocalorimeter | Minicalorimeter 4ml | Microcalorimeter 20ml |
|---|---|---|---|
| sensitivity | < ± 10 nW | < ± 100 nW | < ± 100 nW |
| drift | < 20 nW/24h | < 200 nW/24 h | < 200 nW/24 h |
| accuracy | < 1% | < 5% | < 1% |
| precision | ± 100 nW | ± 200 nW | ± 100 nW |

S. Freund, DBE
TAM air - Isothermal microcalorimeter (brochure)

S. Freund, DBE
TAM ITC (brochure)
Titration unit available 4mL Hasteloy cell and 250μL syringe

S. Freund, DBE
Symcel Calscreener - Isothermal microcalorimeter

S. Freund, DBE
Calbact FAST4U Isothermal microcalorimeter

Differential scanning calorimetry looks at how a material’s heat flow changes as it is steadily heated or cooled, revealing transition events like melting or crystallization. This helps to understand properties like stability, purity, and how a material behaves under temperature changes, all without altering or damaging the sample.

S. Freund, DBE
DSC Q2000 TA instruments – Differential Scanning Calorimeters (brochure)

S. Freund, DBE
Thermography doesn’t measure heat flow inside a sample. Its cameras simply visualize surface temperatures by detecting infrared radiation. The camera converts this invisible heat into a visible image, showing warmer and cooler areas in different colours. This allows people to “see” temperature patterns across surfaces, which can help identify things like heat loss in buildings, overheating equipment, or temperature changes in the human body, all without touching or altering what’s being measured.

S. Freund, DBE
FLIR T860 Thermal Imaging Camera (brochure)