In this project, we aim to measure novel biomarkers in Optical Coherence Tomography Angiography (OCTA) data. OCTA is a non-invasive imaging technique that enables the detection of vessel flow signals in the retina. The OCTA technique is based on laser reflections and thereby similar to Ultrasound, using light instead of sound waves. As the laser scans over the retina, depth information is received at every single location. Hence, OCTA is inherently a volumetric imaging method.

Currently, OCTA data in clinics is mostly displayed as 2D en-face images. These representations provide a detailed analysis of the vascular state. However, using only a 2D-display method, much of the volumetric information is not depicted and the spatial relation between vessels in different layers is not perceivable. Nowadays, advanced computational and storage capacities enable the visualisation of these vascular networks in 3D.

By modifying a commercially available OCTA device and processing the obtained raw data, we aim to detect and measure novel retinal biomarkers. Such a quantitative approach enhances the in-depth characterisation of different retinal diseases and could lead to a better understanding of their pathophysiology. The novel biomarkers could also serve as treatment response parameters for individual patients. Furthermore, the volumetric images will be integrated into the SpectoVR system for intuitive and interactive visualisations of OCTA data.

Project leader: Philippe Valmaggia