Biofabrication and Biosensors

As the biological unit of the Swiss MAM research group, our strength lies in bridging clinical projects and engineering innovations. We focus on developing biologically relevant technologies for use in operating rooms, including biosensors and 3D-printed micro-scaffolds, which hold potential as innovative medical devices.
Our research focuses on advancing musculoskeletal tissue engineering and regenerative medicine through innovative technologies, both in vitro and in vivo. We specialize in developing biological models (2D, 3D, and ex vivo) and Bio3D printing and melt electrowriting for cartilage and bone regeneration [1]. Currently, we are  involved in the development and integration of electrochemical and optical microsensors for real-time monitoring of in vitro cultures and patient applications [2]. Additionally, we are developing in vitro organ-on-chip model for osteoarthritis and inflammation [3].

As part of Swiss MAM, the Biofabrication and Biosensor Unit provides biological and application-oriented support to research teams working in Laser, Robotic 3D Printing, DBM Cartilage, and Calorimetry. We have successfully established a functional BSL2 laboratory for the study and application of mammalian cells and tissues. Our expertise extends beyond conventional validation techniques to include toxicity studies, material science, cell biology and advanced validation methods. Equipped with specialized instrumentation including biological safety cabinets, microscopes, plate readers, ex vivo models, and 3D printing technologies, we support various research projects, with a particular focus on orthopedic and craniomaxillofacial applications, though our scope is not limited to these areas.
To optimize resources and avoid redundancy, we collaborate closely with the Department of Biomedicine, while ensuring access to both in-house equipment and emerging technologies, such as 3D bioprinting, high-voltage 3D printing, and advanced sensor systems.

Swiss MAM MIRACLE II logo

Biofabrication and Biosensor Unit
Part of the Swiss MAM research group
Swiss MAM Website

Group leader: Dr. Valentina Basoli
valentina.basoli@clutterunibas.ch