Selected Publications

1.         Struthoff H, Lauder L, Hohl M, Hermens A, Tzafriri AR, Edelman ER, Kunz M, Böhm M, Tschernig T, Mahfoud F. Histological examination of renal nerve distribution, density, and function in humans. EuroIntervention 2023;19:612-620. doi: 10.4244/EIJ-D-23-00264

2.         Lauder L, Moon LB, Pipenhagen CA, Ewen S, Fish JM, Virmani R, Jensen JA, Böhm M, Mahfoud F. A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model. Clin Res Cardiol 2022;111:595-603. doi: 10.1007/s00392-020-01764-0

3.         Tokcan M, Federspiel J, Lauder L, Hohl M, Al Ghorani H, Kulenthiran S, Bettink S, Böhm M, Scheller B, Tschernig T, Mahfoud F. Characterisation and distribution of human coronary artery innervation. EuroIntervention 2024;20:e1107-e1117. doi: 10.4244/EIJ-D-24-00167

4.         Struthoff H, Lauder L, Federspiel JM, Hohl M, Böhm M, Tschernig T, Mahfoud F. Human nerve distribution and density around the carotid artery bifurcation. Clin Res Cardiol 2024;113:1508-1513. doi: 10.1007/s00392-024-02419-0

5.         Hohl M, Lauder L, Sevimli O, Tokcan M, Wagmann L, Gotzinger F, Schneider C, Hubner U, Lehnert U, Meyer MR, Böhm M, Mahfoud F. Efficacy of Antihypertensive Drugs of Different Classes After Renal Denervation in Spontaneously Hypertensive Rats. Hypertension 2023;80:e90-e100. doi: 10.1161/HYPERTENSIONAHA.122.20756

6.         Hohl M, Selejan SR, Wintrich J, Lehnert U, Speer T, Schneider C, Mauz M, Markwirth P, Wong DWL, Boor P, Kazakov A, Mollenhauer M, Linz B, Klinkhammer BM, Hubner U, Ukena C, Moellmann J, Lehrke M, Wagenpfeil S, Werner C, Linz D, Mahfoud F, Böhm M. Renal Denervation Prevents Atrial Arrhythmogenic Substrate Development in CKD. Circ Res 2022;130:814-828. doi: 10.1161/CIRCRESAHA.121.320104

7.         Tzafriri AR, Garcia-Polite F, Keating J, Melidone R, Knutson J, Markham P, Edelman ER, Mahfoud F. Morphometric analysis of the human common hepatic artery reveals a rich and accessible target for sympathetic liver denervation. Sci Rep 2022;12:1413. doi: 10.1038/s41598-022-05475-6

8.         Sato Y, Sharp ASP, Mahfoud F, Tunev S, Forster A, Ellis M, Gomez A, Dhingra R, Ullman J, Schlaich M, Lee D, Trudel J, Hettrick DA, Kandzari DE, Virmani R, Finn AV. Translational value of preclinical models for renal denervation: a histological comparison of human versus porcine renal nerve anatomy. EuroIntervention 2022. doi: 10.4244/EIJ-D-22-00369

9.         Sharp ASP, Tunev S, Schlaich M, Lee DP, Finn AV, Trudel J, Hettrick DA, Mahfoud F, Kandzari DE. Histological evidence supporting the durability of successful radiofrequency renal denervation in a normotensive porcine model. J Hypertens 2022;40:2068-2075. doi: 10.1097/HJH.0000000000003236

10.       Wolf M, Hubbard B, Sakaoka A, Rousselle S, Tellez A, Jiang X, Kario K, Hohl M, Böhm M, Mahfoud F. Procedural and anatomical predictors of renal denervation efficacy using two radiofrequency renal denervation catheters in a porcine model. J Hypertens 2018;36:2453-2459. doi: 10.1097/HJH.0000000000001840

11.       Lauder L, Ewen S, Tzafriri AR, Edelman ER, Lüscher TF, Blankenstijn PJ, Dorr O, Schlaich M, Sharif F, Voskuil M, Zeller T, Ukena C, Scheller B, Böhm M, Mahfoud F. Renal artery anatomy assessed by quantitative analysis of selective renal angiography in 1,000 patients with hypertension. EuroIntervention 2018;14:121-128. doi: 10.4244/EIJ-D-18-00112

12.       Mahfoud F, Pipenhagen CA, Boyce Moon L, Ewen S, Kulenthiran S, Fish JM, Jensen JA, Virmani R, Joner M, Yahagi K, Tsioufis C, Böhm M. Comparison of branch and distally focused main renal artery denervation using two different radio-frequency systems in a porcine model. Int J Cardiol 2017;241:373-378. doi: 10.1016/j.ijcard.2017.04.057

13.       Linz D, Hohl M, Khoshkish S, Mahfoud F, Ukena C, Neuberger HR, Wirth K, Böhm M. Low-Level But Not High-Level Baroreceptor Stimulation Inhibits Atrial Fibrillation in a Pig Model of Sleep Apnea. J Cardiovasc Electrophysiol 2016;27:1086-1092. doi: 10.1111/jce.13020

14.       Mahfoud F, Moon LB, Pipenhagen CA, Jensen JA, Pathak A, Papademetriou V, Ewen S, Linz D, Böhm M. Catheter-based radio-frequency renal nerve denervation lowers blood pressure in obese hypertensive swine model. J Hypertens 2016;34:1854-1862. doi: 10.1097/HJH.0000000000001021

15.       Linz D, van Hunnik A, Hohl M, Mahfoud F, Wolf M, Neuberger HR, Casadei B, Reilly SN, Verheule S, Böhm M, Schotten U. Catheter-based renal denervation reduces atrial nerve sprouting and complexity of atrial fibrillation in goats. Circ Arrhythm Electrophysiol 2015;8:466-474. doi: 10.1161/CIRCEP.114.002453

16.       Linz D, Hohl M, Schutze J, Mahfoud F, Speer T, Linz B, Hubschle T, Juretschke HP, Dechend R, Geisel J, Rutten H, Böhm M. Progression of kidney injury and cardiac remodeling in obese spontaneously hypertensive rats: the role of renal sympathetic innervation. Am J Hypertens 2015;28:256-265. doi: 10.1093/ajh/hpu123

17.       Tzafriri AR, Keating JH, Markham PM, Spognardi AM, Stanley JR, Wong G, Zani BG, Highsmith D, O'Fallon P, Fuimaono K, Mahfoud F, Edelman ER. Arterial microanatomy determines the success of energy-based renal denervation in controlling hypertension. Sci Transl Med 2015;7:285ra265. doi: 10.1126/scitranslmed.aaa3236

18.       Mahfoud F, Tunev S, Ewen S, Cremers B, Ruwart J, Schulz-Jander D, Linz D, Davies J, Kandzari DE, Whitbourn R, Böhm M, Melder RJ. Impact of Lesion Placement on Efficacy and Safety of Catheter-Based Radiofrequency Renal Denervation. J Am Coll Cardiol 2015;66:1766-1775. doi: 10.1016/j.jacc.2015.08.018

19.       Linz D, Mahfoud F, Linz B, Hohl M, Schirmer SH, Wirth KJ, Böhm M. Effect of obstructive respiratory events on blood pressure and renal perfusion in a pig model for sleep apnea. Am J Hypertens 2014;27:1293-1300. doi: 10.1093/ajh/hpu036

20.       Mahfoud F, Tunev S, Ruwart J, Schulz-Jander D, Cremers B, Linz D, Zeller T, Bhatt DL, Rocha-Singh K, Böhm M, Melder RJ. Efficacy and safety of catheter-based radiofrequency renal denervation in stented renal arteries. Circ Cardiovasc Interv 2014;7:813-820. doi: 10.1161/CIRCINTERVENTIONS.114.001506

21.       Tzafriri AR, Mahfoud F, Keating JH, Markham PM, Spognardi A, Wong G, Fuimaono K, Böhm M, Edelman ER. Innervation patterns may limit response to endovascular renal denervation. J Am Coll Cardiol 2014;64:1079-1087. doi: 10.1016/j.jacc.2014.07.937