Postmortem MRI


A key research focus of our research group is postmortem MRI. Thereby, our approach includes both in-situ and ex-situ MRI scanning, complemented by histological analysis. This method allows for the validation of potential MRI biomarkers against histological ground truth, providing a deeper insight into the pathology of neurodegenerative diseases like amyotrophic lateral sclerosis. Our team also focuses on refining MRI parameters through temperature corrections, a critical factor in in-situ and ex-situ imaging. This is vital for accurate MRI interpretations, particularly in postmortem MRI, where the reduced body temperature can significantly affect the signal intensity and contrast of the MR images. Our research for examples also explores intravoxel incoherent motion assessments, enhancing the understanding of tissue microstructures and fluid dynamics within the brain. Another important aspect of our work is the investigation of brain edema in-situ. This contributes to a better understanding of postmortem brain alterations.