Technologies for Tissue Engineering
The Tissue Engineering Technologies division’s ultimate goal is to generate grafts to repair cartilage and bone tissues, as well as osteochondral lesions. The projects, at the interface between fundamental research and clinical translation, foster competences of 30 biologists, clinicians and engineers.
Beyond a potential clinical use as implants, the engineered constructs also represent invaluable 3D model systems to study progenitor cell differentiation and tissue development. Our research in the context of the DBE will focuson two main aspects, respectively coordinated by PD Dr. Arnaud Scherberich and Dr. David Wendt:
Firstly, the detection and quantification of bone formation and vessel ingrowth in engineered osteogenic grafts in vivo remains a critical issue in bone tissue engineering. To address these unmet needs, we investigate the use of state-of-the-art imaging techniques including: tomography, magnetic resonance with or without contrast agents, and intra-vital staining coupled to two-photon microscopy.
Secondly, engineering 3D cell culture systems is pivotal for the generation of tissue grafts for clinical applications, as well as establishing physiological models to investigate tissue development. To establish and maintain 3D cell cultures, we implement innovative bioreactor systems to increase mass transport throughout the developing tissue, monitor and control key culture parameters, and standardize bioprocesses.
The laboratory is located at the University Hospital Basel, the project page can be found here. The research is funded through public (SNF) or industrial programmes and in the context of European consortia that favour strong international networking of the group.
Prof Dr Ivan Martin
Head of Technologies for Tissue Engineering
Tel: +41 (0)61 265 23 84